解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Coxsackievirus B3 (CVB3) has previously been shown to utilize autophagy in an advantageous manner during the course of infection of the host cell. However, few studies have determined whether stem cells induce autophagy in a similar fashion, and whether virus-induced autophagy occurs following infection of stem cells....
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19781
更新日期:2012-06-01 00:00:00
abstract::A hallmark of macroautophagy is the formation of autophagosomes, double-membrane vesicles that enwrap cellular components destined for lysosomal degradation. We examined autophagosomal protein dynamics under various inducing stimuli using a comprehensive mass spectrometry-based proteomics approach in combination with ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.20286
更新日期:2012-06-01 00:00:00
abstract::The endothelium plays a central role in the regulation of vascular wall cellularity and tone by secreting an array of mediators of importance in intercellular communication. Nutrient deprivation of human endothelial cells (EC) evokes unconventional forms of secretion leading to the release of nanovesicles distinct fro...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19768
更新日期:2012-06-01 00:00:00
abstract::microRNAs (miRNAs) are a class of small regulatory RNAs that regulate gene expression at the post-transcriptional level. miRNAs play important roles in the regulation of development, growth, and metastasis of cancer, and in determining the response of tumor cells to anticancer therapy. In recent years, they have also ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.20053
更新日期:2012-05-01 00:00:00
abstract::Formation of the autophagosome is likely the most complex step of macroautophagy, and indeed it is the morphological and functional hallmark of this process; accordingly, it is critical to understand the corresponding molecular mechanism. Atg8 is the only known autophagy-related (Atg) protein required for autophagosom...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19385
更新日期:2012-05-01 00:00:00
abstract::Autophagy is essential for prolonging yeast survival during nutrient deprivation; however, this report shows that some autophagy proteins may also be accelerating population death in those conditions. While leucine starvation caused YCA1-mediated apoptosis characterized by increased annexin V staining, nitrogen depriv...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19314
更新日期:2012-05-01 00:00:00
abstract::In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update the...
journal_title:Autophagy
pub_type: 指南,杂志文章
doi:10.4161/auto.19496
更新日期:2012-04-01 00:00:00
abstract::Chronic drinking leads to myocardial contractile dysfunction where ethanol metabolism plays an essential role. Acetaldehyde, the main ethanol metabolite, mediates alcohol-induced cell injury although the underlying mechanism is still elusive. This study was designed to examine the mechanism involved in accelerated eth...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.18997
更新日期:2012-04-01 00:00:00
abstract::Reactive oxygen species (ROS) that accumulate under oxidative pressure cause severe damage to cellular components, and induce various cellular responses, including apoptosis, programmed necrosis and autophagy, depending on the cellular setting. Various studies have described ROS-induced autophagy, but only a few direc...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19288
更新日期:2012-03-01 00:00:00
abstract::Inhibition of the autophagic pathway has recently revealed promising results in increasing pro-death activity of multiple cancer therapeutics. Here, we discuss our findings regarding the autophagy-blocking and anti-neoplastic effects of a synthetic sphingosine analog, FTY720, in mantle cell lymphoma (MCL). We also emp...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19050
更新日期:2012-03-01 00:00:00
abstract::Our laboratory has been investigating for some time the nature of the response of T lymphocytes in autoimmunity in the reactions against self-proteins that result in a number of diseases, such as type 1 diabetes, multiple sclerosis, rheumatoid arthritis (RA) and others. T cells recognize peptides generated from protei...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19261
更新日期:2012-03-01 00:00:00
abstract::Lafora disease (LD) is an inherited and fatal form of neurodegenerative disorder characterized by the presence of an abnormal form of glycogen inclusions, called Lafora bodies, in neurons and other tissues. While Lafora bodies have been thought to underlie the neuropathology in LD, the specific process by which these ...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.8.2.19010
更新日期:2012-02-01 00:00:00
abstract::Neuroepithelial cells undergoing differentiation efficiently remodel their cytoskeleton and shape in an energy-consuming process. The capacity of autophagy to recycle cellular components and provide energy could fulfill these requirements, thus supporting differentiation. However, little is known regarding the role of...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.8.2.18535
更新日期:2012-02-01 00:00:00
abstract::Hepatic stellate cell (HSC) activation, the transition from a resident quiescent HSC to a myofibroblastic collagen-producing HSC, is a fundamental feature of liver fibrosis. Autophagy has been implicated in major liver pathologies, such as HCV infection and hepatocarcinoma. However, its role in HSC biology is largely ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.8.1.18105
更新日期:2012-01-01 00:00:00
abstract::A steady increase in life expectancy has resulted in an equivalent increase in elderly patients who are more susceptible to diseases than young patients. In a recent study, we found that in both in vitro and in vivo models of ischemia/reperfusion (I/R), a loss of ATG4B is causatively associated with the increased sens...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.8.1.18391
更新日期:2012-01-01 00:00:00
abstract::Recent publications link mitophagy mediated by PINK1 and Parkin with cardioprotection and attenuation of inflammation and cell death. The field is in need of methods to monitor mitochondrial turnover in vivo to support the development of new therapies targeting mitochondrial turnover. ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.12.18175
更新日期:2011-12-01 00:00:00
abstract::The ability to respond and adapt to changes in the physical environment is a universal and essential cellular property. Here we demonstrated that cells respond to mechanical compressive stress by rapidly inducing autophagosome formation. We measured this response in both Dictyostelium and mammalian cells, indicating t...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.12.17924
更新日期:2011-12-01 00:00:00
abstract::Efavirenz (EFV) is the most widely used non-nucleoside reverse transcriptase inhibitor applied in highly active antiretroviral therapy (HAART), the combined pharmacological treatment of the human immunodeficiency virus infection. Its use has been associated with the development of several adverse events including hepa...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.11.17653
更新日期:2011-11-01 00:00:00
abstract::(Macro)autophagy is a membrane-trafficking process that serves to sequester cellular constituents in organelles termed autophagosomes, which target their degradation in the lysosome. Autophagy operates at basal levels in all cells where it serves as a homeostatic mechanism to maintain cellular integrity. The levels an...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.11.16646
更新日期:2011-11-01 00:00:00
abstract::Bacterial intrusion of host cells can be recognized by the innate immune system, including autophagy, via multiple cellular pathways. We have identified Tecpr1 as an Atg5-binding partner, and found that Tecpr1 interacts with the Atg12-Atg5-Atg16L1 complex via binding to Atg5. In Shigella infected cells, Tecpr1 colocal...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.11.17151
更新日期:2011-11-01 00:00:00
abstract::Single microRNA (miRNA) can regulate expression of several or multiple principal targets in a specific microenvironment. In different cellular contexts, the same miRNA may exhibit diverse functions, depending on the repertoire and stoichiometry of its direct mRNA targets. For instance, in breast cancer, microRNA-10b (...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.11.17371
更新日期:2011-11-01 00:00:00
abstract::Increasing evidence suggests that misfolded proteins and intracellular aggregates contribute to cardiac disease and heart failure. We wished to determine if autophagic induction by Atg7 is sufficient to reduce misfolded protein and aggregate content in protein misfolding-stressed cardiomyocytes. We used loss- and gain...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.10.16882
更新日期:2011-10-01 00:00:00
abstract::Mitochondrial morphological and structural changes play a role in several cellular processes, including apoptosis. We recently reported that mitochondrial elongation is also critical to sustain cell viability during macroautophagy. During macroautophagy unopposed mitochondrial fusion leads to organelle elongation both...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.10.16771
更新日期:2011-10-01 00:00:00
abstract::Multiple stress pathways result in the induction of autophagy and apoptosis. Current methods (e.g., protein gel blot, microscopy) do not offer quantitative single-cell resolution, thus making it difficult to discern if these pathways are mutually exclusive or, in some situations, cooperative in executing cell death. W...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.9.16252
更新日期:2011-09-01 00:00:00
abstract::Quercetin, a dietary antioxidant present in fruits and vegetables, is a promising cancer chemopreventive agent that inhibits tumor promotion by inducing cell cycle arrest and promoting apoptotic cell death. In this study, we examined the biological activities of quercetin against gastric cancer. Our studies demonstrat...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.9.15863
更新日期:2011-09-01 00:00:00
abstract::Atg8 and its homologs are essential for autophagosome formation in various species. In animal cells, Atg8 homologs have an additional function in clearance of damaged organelles and bacteria, acting as a landmark for selective autophagy. We have recently shown that OATL1, a Rab-GTPase-activating protein (Rab-GAP), is ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.9.16178
更新日期:2011-09-01 00:00:00
abstract::Although several oncogenes enhance autophagic flux, the molecular mechanism and consequences of oncogene-induced autophagy remain to be clarified. We have recently shown that expression of oncogenic H-Ras (V12) promotes autophagy through upregulation of Beclin 1 and the BH3-only protein Noxa. H-Ras-expressing cells un...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.8.15821
更新日期:2011-08-01 00:00:00
abstract::Protein synthesis and autophagy work as two opposing processes to control cell growth in response to nutrient supply. The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) pathway, which acts as a master regulator to control protein synthesis, has recently been shown to inhibit autophagy by phosphorylating ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.7.15491
更新日期:2011-07-01 00:00:00
abstract::The extensive autophagic-lysosomal pathology in Alzheimer disease (AD) brain has revealed a major defect: in the proteolytic clearance of autophagy substrates. Autophagy failure contributes on several levels to AD pathogenesis and has become an important therapeutic target for AD and other neurodegenerative diseases. ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.7.15596
更新日期:2011-07-01 00:00:00
abstract::The acetylase inhibitor, spermidine and the deacetylase activator, resveratrol, both induce autophagy and prolong life span of the model organism Caenorhabditis elegans in an autophagydependent fashion. Based on these premises, we investigated the differences and similarities in spermidine and resveratrol-induced auto...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.6.15191
更新日期:2011-06-01 00:00:00
abstract::The dysregulation of mitochondrial function has been implicated in the pathogenesis of Parkinson disease. Mutations in the parkin, PINK1 and DJ-1 genes all result in recessive parkinsonism. Although the protein products of these genes have not been fully characterized, it has been established that all three contribute...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.5.14684
更新日期:2011-05-01 00:00:00
abstract::We investigated the cell-death mechanisms induced in esophageal cancer cells in response to the chemotherapeutic drugs, 5-fluorouracil (5-FU) and cisplatin. Chemosensitive cell lines exhibited apoptosis whereas chemoresistant populations exhibited autophagy and a morphology resembling type II programmed cell death (PC...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.6.15066
更新日期:2011-05-01 00:00:00
abstract::Autophagy acts as an intrinsic defense system against intracellular bacterial survival. Recently, multiple cellular pathways that target intracellular bacterial pathogens to autophagy have been described. These include the Atg5/LC3 pathway, which targets Shigella, the ubiquitin (Ub)-NDP52-LC3 pathway, which targets Gr...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.7.3.14581
更新日期:2011-03-01 00:00:00
abstract::Phagocytosis of naturally dying cells usually blocks inflammatory reactions in host cells. We have recently observed that clearance of cells dying through autophagy leads to a pro-inflammatory response in human macrophages. Investigating this response further, we found that during engulfment of MCF-7 or 293T cells und...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.3.14583
更新日期:2011-03-01 00:00:00
abstract::Minocycline has been shown to alleviate several neurological disorders. Unexpectedly, we found that minocycline had opposite effects on glioma cells: minocycline induced nonapoptotic cell death in glioma cells. The glioma cell death was associated with the presence of autophagic vacuoles in the cytoplasm. Minocycline ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.2.14043
更新日期:2011-02-01 00:00:00
abstract::Macroautophagy sequesters superflous cytosol and organelles into double-membraned autophagosomes. Over 30 autophagy-related (ATG) genes have been identified without elucidating the molecular details of autophagosome biogenesis. All proposed models for autophagosome formation require membrane fusion events (Fig. 1). Pr...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.2.14383
更新日期:2011-02-01 00:00:00
abstract::Macroautophagy is a major lysosomal degradation pathway for cellular components in eukaryotic cells. Baseline macroautophagy is important for quality control of the cytoplasm in order to avoid the accumulation of cytotoxic products. Its stimulation by various stressful situations, including nutrient starvation, is imp...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.1.13851
更新日期:2011-01-01 00:00:00
abstract::The vascular system of plants consists of two conducting tissues, xylem and phloem, which differentiate from procambium cells. Xylem serves as a transporting system for water and signaling molecules and is formed by sequential developmental processes, including cell division/expansion, secondary cell wall deposition, ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.8.13429
更新日期:2010-11-01 00:00:00
abstract::Autophagy is one of the survival processes of cancer cells, especially in stressful conditions such as starvation, hypoxia and chemotherapeutic agents. However, its roles in tumor survival have not yet been fully elucidated. Here, we found for the first time that JAK2/STAT3 was activated in HeLa cells when they were s...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.8.13547
更新日期:2010-11-01 00:00:00
abstract::Recent studies have suggested that autophagy is involved in a neural death pathway following cerebral ischemia. In vivo detection of autophagy could be important for evaluating ischemic neural cell damage for human stroke patients. Using novel green fluorescent protein (GFP)-fused microtubule-associated protein 1 ligh...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.8.13427
更新日期:2010-11-01 00:00:00